A position for
a postdoctoral scientist is available in the laboratory of Dr Judith Sleeman at
the Biomedical Sciences Research Complex (BSRC), University of St Andrews, to
study the involvement of the paraspeckle nuclear domain in Myotonic Dystrophy
Type 1.
The Sleeman lab
is interested in how defects in RNA metabolism and cellular structure are
associated with inherited human neuromuscular diseases including Myotonic
Dystrophy Type 1 (DM1) and Spinal Muscular Atrophy (SMA). The significance of
accurate regulation of RNA production, processing and function is clear from
the increasing number of diseases in which defects in RNA metabolism are
implicated. We are primarily interested in the physical organisation of RNA
processing within mammalian cells, and use techniques including fixed and
live-cell microscopy, advanced fluorescence microscopy techniques, electron
microscopy and proteomics to address our research questions (Clelland et al,
2012; Coleman et al 2014; Prescott et al 2014).
The post will
be for 15 months in the first instance with likely extension for a further 12
months. The project is funded by Muscular Dystrophy UK and is a collaboration
with Dr Archa Fox, Perth, Australia. Candidates must hold a PhD in Biological
Sciences (or equivalent). A strong background in cell biology is essential. We
especially welcome applications from candidates with a keen interest and
experience in microscopy and image analysis or proteomics. Knowledge of RNA
metabolism and experience working with RNA are desirable.
We offer an
exciting and stimulating work environment with local and international
scientific collaborations. The BSRC conducts world-class multidisciplinary
research spanning Biology, Chemistry, Physics and Medicine. It houses
world-class mass spectrometry and microscopy facilities, as well as expertise
in advanced optical techniques and single-molecule visualization.
Besides a great
research environment, St Andrews provides a beautiful place to live, with the
sea on the doorstep and Edinburgh and the Highlands only about 1.5 hours’ drive
away.
More
information on the lab can be found at: http://synergy.st-andrews.ac.uk/sleeman/
Informal
enquiries are encouraged and can be made to Dr Judith Sleeman (e-mail: jes14@st-andrews.ac.uk)
The University of St Andrews is
committed to promoting equality of opportunity for all, which is further
demonstrated through its working on the Gender and Race Equality Charters and
being awarded the Athena SWAN award for women in science, HR Excellence in
Research Award and the LGBT Charter; http://www.st-andrews.ac.uk/hr/edi/diversityawards/.
Closing Date: 11 November 2017
Interview Date: 27
November 2017
Please quote ref: AR1834HM
Further Particulars: AR1834HM FPs.doc
Biomedical Sciences Research Complex
Salary: £32,548
Start Date: As soon as possible
Fixed Term for: 15 Months
Research Fellow - AR1834HM
Research Fellow - AR1834HM