You will join a productive, collaborative research group in the new Biomedical Sciences Research Complex at the University of St. Andrews. You will study the interaction of a major bacterial virulence protein with human collagen-derived peptides, using solution state NMR spectroscopy, microcalorimetry and Xray-crystallography. This research will contribute to the development of urgently required new strategies for the diagnosis and treatment of infections caused by Streptococcus pyogenes, one of the top ten most deadly human pathogens. This project aims to determine the molecular basis for the induction of anti-collagen antibodies in streptococcal autoimmune sequelae.

You will have a strong background in molecular biology, protein biochemistry and structural biology. You should be proficient in molecular biology and protein expression. Experience with either biomolecular NMR, Xray crystallography or other biophysical techniques is desirable.

Informal enquiries to: Dr Uli Schwarz-Linek (us6@st-andrews.ac.uk, +44 (0)1334 467188).

Interviews will be held in the week beginning 20 February 2012

Ref No: ML1095

Closing Date: 8 February 2012

Further Particulars ML1095 FPs.doc

School of Biology/Biomedical Sciences Research Complex
£29,972 - £35,788 per annum
Start: February 2012 or as soon as possible thereafter
Fixed Term: 12 months