Research Fellow - AR1834HM

A position for a postdoctoral scientist is available in the laboratory of Dr Judith Sleeman at the Biomedical Sciences Research Complex (BSRC), University of St Andrews, to study the involvement of the paraspeckle nuclear domain in Myotonic Dystrophy Type 1.

The Sleeman lab is interested in how defects in RNA metabolism and cellular structure are associated with inherited human neuromuscular diseases including Myotonic Dystrophy Type 1 (DM1) and Spinal Muscular Atrophy (SMA). The significance of accurate regulation of RNA production, processing and function is clear from the increasing number of diseases in which defects in RNA metabolism are implicated. We are primarily interested in the physical organisation of RNA processing within mammalian cells, and use techniques including fixed and live-cell microscopy, advanced fluorescence microscopy techniques, electron microscopy and proteomics to address our research questions (Clelland et al, 2012; Coleman et al 2014; Prescott et al 2014).

The post will be for 15 months. Flexible and part-time working can be considered. The project is funded by Muscular Dystrophy UK and is a collaboration with Dr Archa Fox, Perth, Australia. Candidates must hold a PhD in Biological Sciences (or equivalent). A strong background in cell biology is essential. We especially welcome applications from candidates with a keen interest and experience proteomics. Knowledge of mammalian RNA metabolism and experience in microscopy and image analysis are desirable.

We offer an exciting and stimulating work environment with local and international scientific collaborations. The BSRC conducts world-class multidisciplinary research spanning Biology, Chemistry, Physics and Medicine. It houses world-class mass spectrometry and microscopy facilities, as well as expertise in advanced optical techniques and single-molecule visualization. The position will be based in brand new laboratory space on the North Haugh site.

Besides a great research environment, St Andrews provides a beautiful place to live, with the sea on the doorstep and Edinburgh and the Highlands only about 1.5 hours’ drive away. Caring costs up to £200 associated with interviews will be covered by the School if appropriate.

More information on the lab can be found at:

Informal enquiries are very strongly encouraged and can be made to Dr Judith Sleeman (e-mail: or Dr Dave Hughes (

The University is committed to equality for all, demonstrated through our working on diversity awards (ECU Athena SWAN/Race Charters; Carer Positive; LGBT Charter; and Stonewall).  More details can be found at
The University of St Andrews School of Biology was awarded the Athena SWAN Silver award in 2018 for its sustained progression and achievement in advancing equality and representation. The School particularly welcomes applications from those suitably qualified from underrepresented minorities. The School values equality and diversity across its workforce and offers a family friendly environment in which flexible working is encouraged; we strive to hold important meetings/seminars within core hours of 09.15 to 14.45. In addition, a broad variety of measures are currently being introduced to ensure effective career progression for everyone and to eradicate the historical underrepresentation of females at higher professional levels.

Closing Date: 4 November 2019       
Interview Date: 21 November 2019

Please quote ref: AR1834HM   

Further Particulars: AR1834HM FPs.doc

School of Biology
Salary: £33,797 per annum
Start Date: As soon as possible
Fixed Term for 15 months

Research Fellow - AR1834HM