Research Associate (Biocatalysis) – AR2418RDD
We require a committed researcher to work in a collaborative project between Dr Clarissa Czekster
(School of Biology), Professor David Harrison (School of Medicine) and NuCana
plc which is headquartered in Edinburgh. The work will entail developing novel
enzyme catalysts to contribute to NuCana’s early Drug Discovery and Drug
Development studies.
The successful applicant will incorporate enzymes into the synthetic
route used to produce a set of ProTide prodrugs known to possess antiviral and
anticancer activity. They will apply technologies such as site directed
mutagenesis and directed evolution to enzymes of interest to expand their substrate
scope and efficiency.
They will take responsibility for the characterisation of enzyme
variants, as well as optimization of reaction conditions and ProTide
characterization.
The successful candidate will be aware of specific requirements of industry/academic
collaborations, and prior industrial experience is highly desirable. Prior experience with directed evolution and/or
enzyme evolution is an essential criterium.
He/she will be reliable, creative, knowledgeable and hard-working, capable of delivering
high-quality data in a timely manner. The successful applicant will have all
the necessary support from the supervisor, the group, and their collaborators,
but you will be expected to be able to work independently and as part of a team
as required. Problem-solving skills, leadership, and scientific rigour are
essential traits.
This position is fixed term for 24 months. Informal
enquiries can be directed to Dr Clarissa Czekster, cmc27@st-andrews.ac.uk
Applications are
particularly welcome from women, people from the Black, Asian, Minority or
Ethnic (BAME) community and other protected characteristics who are
under-represented in research posts at the University.
The University is
committed to equality for all, demonstrated through our working on diversity
awards (ECU Athena SWAN/Race Charters; Carer Positive; LGBT Charter; and
Stonewall). More details can be found at
http://www.st-andrews.ac.uk/hr/edi/diversityawards/.
Closing Date: 30th November 2020
Please quote ref: AR2418RDD
Further particulars: AR2418RDD FPs.doc
School of Biology
Salary: £33,797 per annum
Start Date: 1st January 2021 or as soon as possible
Fixed Term: 24 months
Research Associate (Biocatalysis) – AR2418RDD